Director, Preclinical Project Development and Strategic Lead

Company: Legend Biotech
Location: Somerset
Posted on: February 5, 2026

Job Description:

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide. Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma. Legend Biotech is seeking a Director, Preclinical Project Development and Strategic Lead as part of the Early-stage Drug Development team based in Somerset, NJ. Role Overview The Preclinical development and strategic lead is responsible for planning, executing and overseeing preclinical development projects of Legend. He or she will be responsible for managing cross-functional team, ensuring adherence to IND submission timelines, budgets and regulatory requirements and acting as central point of communication between stakeholders to advance Legend drug development efforts. Key Responsibilities Preclinical IND enabling study oversight Work closely with program teams to develop preclinical IND strategies. Accountable for preclinical IND study delivery and quality Developing and mange project plans, timelines, budgets and resources for preclinical IND programs Coordinate and monitor preclinical studies, including in vitro and in vivo studies, ensuing alignment with program goals Track project progress, identify risks and implement mitigation strategies to maintain timelines and deliverables Cross functional collaboration Serve as a liaison between internal departments (eg, research, toxicology, pharmacology, CMC, regulatory affairs) and eternal partners (e.g. CROs) Facilitate communication and collaboration among multidisciplinary teams to achieve project milestones Ensure preclinical studies comply with relevant regulatory guidelines (e.g., GLP, FDA, EMA). Prepare or support the creation of regulatory submissions, including pre-IND packages and investigator brochures. Data Management and Reporting: Oversee data collection, analysis, and documentation for preclinical studies. Prepare project reports, presentations, and summaries for internal and external stakeholders. Vendor and Budget Management: Identify, evaluate, and manage relationships with contract research organizations (CROs) and other external vendors. Negotiate contracts, oversee budgets, and ensure high-quality deliverables from external partners. Strategic Input: Contribute to the design and development of preclinical study strategies to support clinical translation. Provide input on program development based on emerging data and scientific trends. Requirements PhD in biology and biochemistry or related field At least 10 years of relevant work experience, including a minimum of 5-8 years of preclinical research and development experience in pharmaceutical or biotech industry. Experience in IND submission of cell or therapies. Familiarity with preclinical drug development processes, regulatory guidelines, and GLP standards. Preclinical project lead in IND submission Strong organizational and project management skills, with the ability to manage multiple projects simultaneously. Excellent communication and interpersonal skills for cross-functional collaboration and stakeholder engagement. Knowledge of regulatory requirements and preclinical study design principles Experiences in preclinical research especially in cell therapy preclinical development is preferred Experience working with CROs and managing external collaborations. Certification in project management (e.g., PMP, PRINCE2) is a plus. Li-JK1 Li-Hybrid The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws. Performance-based bonus and/or equity is available to employees in eligible roles. The anticipated base pay range is: $187,989 - $246,737 USD Benefits Benefits include medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work. Please note: These benefits are offered exclusively to permanent full-time employees. Contract employees are not eligible for benefits through Legend Biotech. EEO Statement It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances. Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions. For information related to our privacy policy, please review: Legend Biotech Privacy Policy.

Keywords: Legend Biotech, Brentwood , Director, Preclinical Project Development and Strategic Lead, Science, Research & Development , Somerset, New York